Lipase is an enzyme that breaks down dietary fats and oils, supporting digestive health by relieving indigestion, bloating, and flatulence after high-fat meals, while potentially aiding nutrient absorption, immune function, metabolic processes, and pancreatic health, making it beneficial for those with deficiencies or conditions affecting fat digestion.
A lipase is a type of enzyme that hydrolyzes lipids, meaning that it breaks down fats. These enzymes perform a variety of functions involving the digestion and transportation of dietary lipids such as fats, oils and triglycerides.
Animal fat is the primary dietary source of lipase. Commercial sources of lipase are usually animal fat as well, although some types of bacteria also contain significant amounts of lipase. Traditional uses of lipase include the manufacture of fermented dairy products such as cheese and yogurt. Lipases are also being used in biotechnology applications like the conversion of vegetable oil into fuel.
Lipases play important roles in biology since cell membranes are primarily composed of phospholipids. Important lipases in the human digestive system include HPL, endothelial lipase, hepatic lipase and lipoprotein lipase. The lipases may also have functions outside the digestive system, and their concentrations in the blood may be used as markers to help diagnose problems of the pancreas. The role of lipase in health supplements is primarily related to making digestion easier due to their ability to break down fat.
The most common use of lipase is to help support digestive health. It also supports metabolic syndrome and may help support the immune system. Additional benefits of lipase include improved nutrient absorption.
Lipase may help support the immune system and healthy inflammation management.
Lipase may help relieve the discomfort of indigestion, including bloating and flatulence. It is most beneficial after a high-fat meal.
Lipase may help support the immune system and healthy inflammation management.
Lipase helps support metabolic syndrome and healthy pancreatic functions, especially those that occur as a normal part of the aging process.
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Digestive difficulties are the most common sign that you may need more lipase, especially if they occur after a high-fat meal. These are often associated with the removal of the gall bladder, which secretes the bile needed to digest fat. People who need help in maintaining a healthy cholesterol profile may also get support from lipase, especially when combined with a low-fat diet.
HPL, endothelial lipase, hepatic lipase, lipoprotein lipase
Most people do not need additional lipase. However, people with the following conditions may find lipase supplements helpful.
Celiac disease is a condition in which gluten (a protein found in grains) damages the intestinal tract. Symptoms include abdominal pain, bloating, weight loss, and fatigue. People with celiac disease must follow a strict diet that is free of gluten. Pancreatic enzymes have been studied as part of the treatment for celiac disease, however, it is not clear how much they help. In one study of 40 children with celiac disease, for example, those who received pancreatic enzyme therapy (including lipase), had a modest weight gain compared to those who received placebo. The weight gain happened during the first month. Taking pancreatic enzyme supplements for another month did not lead to more weight gain.
In a small clinical study of 18 people, supplements containing lipase and other pancreatic enzymes helped reduce bloating, gas, and fullness following a high-fat meal. These symptoms are commonly associated with irritable bowel syndrome (IBS). So some researchers speculate that pancreatic enzymes might help treat symptoms of IBS. No studies have been done to test this theory.
People with cystic fibrosis, an inherited condition that causes the body to produce abnormally thick, sticky mucus, often have nutritional deficiencies because mucus blocks pancreatic enzymes from getting to the intestines. Taking pancreatic enzymes as prescribed by a doctor helps improve the nutrition they get from food.