Do you need to heat-inactivate serum in PETG Media Bottles

As a company focused on high-end biologic consumables, we can address the question of whether serum needs to be heat-inactivated in PETG Media Bottles.

PETG Media Bottles are transparent packaging containers primarily used for storing and sampling active pharmaceutical ingredients and bulk intermediates. They are also well-suited for preparing and storing solutions such as buffers, serum, and culture media. As a company focused on high-end biologic consumables, we can address the question of whether serum needs to be heat-inactivated in petg media bottles.

Firstly, it's important to note that there are different types and qualities of serum. Some expensive serums contain valuable substances such as growth factors, vitamins, and amino acids. These substances can be damaged during heat inactivation of serum, leading to negative effects such as turbidity in the culture medium within the transparent petg media bottles, which can affect cell growth. For example, when it comes to fetal bovine serum (FBS), the most common method for heat inactivation in petg media bottles is heating at 56°C for 30 minutes.

However, with advancements in life sciences in recent years, many reasons previously considered necessary for heat inactivation no longer hold true due to improvements in serum collection, processing, and manufacturing processes. Heat inactivation is aimed at removing heat-sensitive substances like complement from serum, but it's evident that heat inactivation of complement in fetal bovine serum is not necessary.

Of course, it's essential to consider whether serum in petg media bottles has undergone mycoplasma testing by the manufacturer. Heat treatment of serum in petg media bottles can effectively inactivate mycoplasma. Additionally, with the use of small-pore, multi-layer, continuous filtration nanotechnology by some companies, the possibility of mycoplasma contamination is minimized.

In conclusion, whether serum in petg media bottles needs heat inactivation requires consideration from multiple perspectives. As a manufacturer specializing in petg media bottles for serum storage, we offer products made from PET and PETG materials, ensuring sterility, enzyme-free, and free from precipitation. These bottles can be stored at low temperatures and are available in various capacities ranging from 5ml to 1000ml to suit your needs.